Jack Bauer (Kiefer Sutherland) must once again save the day. This time, the threat comes from a lethal virus linked with a couple of drug-running brothers, Ramon and Hector Salazar (Joaquim de Almeida and Vincent Laresca). Bauer has a personal connection with them because he went undercover to get Hector Salazar convicted. In the process, he also got addicted to heroin. Jack pretends to have gone rogue and breaks Hector Salazar from prison in an effort to get a lead on the virus. Bauer also encounters an old foe, Nina Myers (Sarah Clarke), his wife's murderer. After a series of other twists, the virus ends up in the hands of Stephen Saunders (Paul Blackthorne), who unleashes it on a hotel in L. A. Bauer manages to get Saunders to reveal the whereabouts of vials of the virus and with his partner Chase Edmonds (James Badge Dale) the search starts to contain them.
At the end of the harrowing day, Jack has broken down in tears.
